[4] In 1902, Jeppe first heard about the persecutions of the Armenians in the Ottoman Empire, from her school headmaster H. C. Frederiksen (called also Friser) who presented an article written by Aage Meyer Benedictsen (1866–1927),[5] a Danish-Jewish-Icelandic linguist, writer, philologist and a secular antiimperialist intellectual.

When Benedictsen returned to Denmark in 1902, he took the initiative to found the secular organization of the Danish Friends of Armenians ("Danske Armeniervenner" DA).

In 1909, after the Adana massacres, Jeppe continued her work in providing the daily bread for the Armenians, buying a piece of land in the mountains, where she planted vineyards, and building up good relations with Kurds and Arabs.

Jeppe tried to organize rescue efforts and help the Armenian refugees driven through Urfa, on their way to the death camps in the Syrian desert of Deir ez-Zor, providing food and water and hiding many of them under the floor of her house.

[3][11][12] It was set up under the auspices of the League of Nations to recover Armenian women and children who had been forcibly "absorbed" (a neutral term coined by Ara Sarafian - terms used contemporaneously included "kidnapped", "abducted", and "taken into slavery") into Turkish, Kurdish, and Bedouin households during the genocide, and to reintegrate them into the Armenian community.

[5][14] In 1924, after negotiations with a wealthy Bedouin sheik, Hadjim Pasha, Jeppe rented parts of his lands to the west of Aleppo in the valley of the Euphrates, at a fair price.

[5][16] Hadjim Pasha became a good friend of Karen Jeppe, helping her with practical things and maintaining the security of the new Armenian settlers through his status and the effect that he had in the region.