Karen Kilgariff (born May 11, 1970, in Petaluma, California) is an American writer, comedian, singer, author, actress, television producer, and podcast host.

She began her career as a stand-up comedian in the early 1990s and later became a television actress, most notably as a cast member on Mr. Show.

[4][5] Along with Hardstark, Kilgariff wrote the non-fiction book Stay Sexy and Don't Get Murdered, which was released on May 28, 2019.

[6][7] Karen Kilgariff grew up outside Petaluma, California with her mother Patricia (née Knight), who died in 2016, her father Jim, and her older sister Laura.

In 2015, Kilgariff teamed up with Drennon Davis to record a live album of comedy songs titled I Don't Care, I Like It.

Kilgariff served as the head writer for The Rosie Show, which aired on the Oprah Winfrey Network.

In April 2019, the network's first original podcast Jensen and Holes: The Murder Squad debuted at number one.