[1] Kasese is located approximately 380 kilometres (240 mi) west from Kampala, Uganda's capital and largest city, 40 kilometres (25 mi) north-east of Mpondwe, a town at the international border between Uganda and the Democratic Republic of the Congo (DRC).

On 27 August 2014, the census and national housing survey enumerated 101,065 people in Kasese Town Council.

[5] In 2020, the Uganda Bureau of Statistics (UBOS), estimated the mid-year population of the town at 115,400 inhabitants.

UBOS calculated that the population of Kasese Municipality increased at an average rate of 2.3 percent annually, between 2014 and 2020.

The reasons for this rapid population growth include:[6] Kasese Cobalt Company Limited (KCCL), located on the road from Kasese to Rubirizi just south of the central business district of Kasese, extracts cobalt from the sludge left after copper is extracted from the raw ore.[8] The following points of interest lie within the town or close to its edges: