The South and West Kassikaityu Rivers were penetrated with extensive cutting to points respectively 32 and 38 km (20 and 24 mi) from their confluence.

Subsequently, the Kassikaityu area is referred to by the Wai-wais as the ‘River of the Dead.’[4] In 1934, the British Guiana-Brazil Boundary Commission was set up to survey the boundary reached the upper Essequibo, until the team was impacted by beri-beri and were medically evacuated from the area, one who died was buried on the right bank of the Kassikaityu River.

The commission's work recommenced in 1935 and the British contingent was led by the Army's Royal Engineers.

[5] In 2014, plans were made to construct a tractor trail from Parabara to the Kassikaityu River landing for the benefit of Wai-Wai people to connect to the Rupununi.

It is one of the most remote areas of Guyana, and in addition to practicing traditional ways of life, engage in sustainable tourism.