The Kwitaro is a part of the Rewa River Basin, which is a tributary of the Rupununi River in the larger Essequibo drainage system and within Upper Takutu-Upper Essequibo.

River depth is highly variable,[2] and water level by altimetry varies from a low of 86.53 m. to a high of 94.28 m.; averaging 89.30 m.[3] Vegetation is lowland seasonally inundated and terra firma evergreen tropical forest.

[2] The area is mostly untouched, but has had human impact evidenced from slashes on balata trees that indicate bleeding for latex.

[5][6] Amerindian villages that are a part of the Kwitaro River ecosystem include Aishalton, Awarewaunau, Maruranau and Shea.

This article related to a river in Guyana is a stub.