In 1916 after an unsuccessful revolt against Tsarist authorities, most of the residents of Issyk-Kul, fleeing Russian troops, escaped to the Republic of China, Kasym and his parents were among them.

In 1924, Kasym Tynystanov, O. Aliev, B. Daniyarov and several others formed a Scientific Commission, which developed a Kyrgyz alphabet based on Arabic script.

As a result of the discussion the Convention decided to include in the agenda of the coming Scientific and Educational Congress the issue of transferring from Arabic-based script to a new Latin based one.

The Congress of May 1925 accepted Kasym's proposal and issued a resolution indicating activities related to the process of transfer.

The National Scientific Commission created a Society of Supporters of the New Alphabet, chaired by Kasym Tynystanov, which started to promote understanding and use of the new script.

In 1926 member of the Turkologists Congress, which took place in Baku, widely supported the idea of adequacy of Latin script to peculiarities of Turkic languages.

In one and a half year after the Turkologists Congress a Committee for a New Kyrgyz Alphabet is created within DPE, with Kasym as its deputy chair.

In 1928 to meet the lack of periodicals in Kyrgyz, Kasym Tynystanov, Torokul Aytmatov and several others initiated the creation of a first scientific and educational journal Jangy Madaniyat Jolunda.

Under Kasym's guidance for the People's Commissariat created ethnographic research sub-departments of the Scientific Council the first National Museum and the historic and geographic society, as well as the Committee of the New Alphabet.

Being the Chair of the Commisariat Kasym Tynystanov continued to develop the concepts for coordination of the research and education in Kyrgyzstan.

He considered terminology as a separate trend in Kyrgyz language study, so he laid out its main principles and the methods for composition of so-called term systems.

A deep grammar research as well as detailed study of word inflection and formation patterns allowed Kasym to open "morphonology", a new trend in linguistics.

Based on the findings related to his study of grammar patterns, he managed create a smart algorithm of word formation, which he expressed in his "Technical table".

Based on such analysis he introduced such fundamental trends in Kyrgyz linguistics as Textual Criticism (Textology) and Dialectology.

Since then his work concentrated on analyzing, preservation and publishing of Sayakbai Karalaev's and Sagynbai Orozbakov's versions of the Manas epic.

Kasym wrote that Manas is the source of original Kyrgyz oral poetry and should be considered a part of the world cultural heritage.

He also presented a report at the USSR Conference on Manas Study, held in Frunze city in December 1935, where together with Mukhta Auezov and Evgeniy Polivanov he emphasized the importance preserving the epic.

As for his academic titles, in 1934 Kasym Tynystanov became Senior Scientific Fellow and later an Active Member of Kyrgyz Research Institute of Culture.

As the Chair of the People's Commissariat of Education, Kasym contributed to the development of Kyrgyz soil science, botany, zoology, economics, agriculture, etc.

Intensive work caused numerous health problems, and he voluntarily left the post of the Chair of the People's Commissariat of Education.