Katafygio (Greek: Καταφύγιο, meaning refuge, shelter, lodge) is a village in Aetolia-Acarnania in Greece at an altitude of 620 metres in the eastern foothills of Makrynoros.

It borders the villages of Anavriti to the north, Kentriki and Aspria to the northeast, Chrysovo to the southeast, Gavros to the northwest and Anthofyto to the southwest.

The houses and the fields are strengthened with low walls (demata) in order to stabilise the ground.

In 1928, it was renamed Katafygio because under Ottoman occupation the village was a refuge, with many caverns, and rocky and steep terrain making it hard to reach.

Around 1700 families of cattle-breeders moved to the western side of the Makrynoro mountain and created a small settlement, named Golemi.