On October 8, 2000, she gave birth to twin girls, Cara Nicole and Madelyn "Mady" Kate, who were premature at 35 weeks gestation.

With high ratings from the specials, Discovery Health signed the couple to a reality series which began airing in April 2007, called Jon & Kate Plus 8, documenting their lives.

The show was canceled during season five following Jon's decision to withdraw from the series, with the last episode—the finale of that season—airing on November 23 of that year.

By late December 2009, it was announced that Gosselin was no longer being considered for the role, having been deemed too controversial by executives, and the show had not been picked up by a network by the end of the year.

[12] Gosselin was a contestant in the tenth season of Dancing with the Stars,[13] and was partnered with professional dancer Tony Dovolani.

[citation needed] On March 19, 2014, it was announced that Gosselin and her eight children would return for a reunion special of Kate Plus 8, scheduled to air in June of the same year.

Her first book, written with Jon Gosselin and Beth Carson, was published in November 2008, titled: Multiple Blessings.

[18] Her third book, titled I Just Want You To Know, was released on April 13, 2010, selling approximately 10,000 copies in its first week and debuting at number 11 on The New York Times Best Sellers list.

According to TLC, Jon and Kate had moved the focus away from the family and the change in the dynamic, as well as the production difficulties that had occurred because the couple was no longer living together, made it unclear whether the show was still viable.

[21] On August 13, 2009, the police were called to the Gosselin family home in Wernersville, Pennsylvania, after the couple were engaged in a verbal fight.

[27] On August 22, 2017, the police were called to an orthodontist's office in Wyomissing, Pennsylvania, after Jon and Kate got into a custody dispute over one of their sextuplet daughters.

No one was arrested, and in the end, the daughter went home with Jon while Kate was referred to Berks County District Attorney's office for a clearer interpretation of the child custody agreement.

It was reported that in April 2018, a judge ruled in favor of Jon having custody of Hannah, which prompted Kate to appeal this decision on May 4, 2018.

[31] On December 4, 2018, Jon won sole physical and legal custody of Collin, as Kate and her attorney failed to appear.

[34] In August 2019, In Touch Weekly reported that Kate was not attempting to win custody of either Hannah or Collin from her ex-husband.

[36] In March 2021, Gosselin relocated to Troutman, North Carolina, with four of her children; Alexis, Aaden, Leah, and Joel.