It is located 3 km (1.9 mi) from the centre of town on the banks of the Katherine River, overlooking Knott's Crossing.

[1] The renal dialysis unit open in May 2000, providing an option for ongoing treatment for kidney disease.

[4] The hospital employs Aboriginal liaison and support officers and is regularly visit by specialists from Darwin.

[5] In the 2011-2012 financial year, Katherine District Hospital conducted 440 elective surgeries and handled 14,311 Emergency Department presentations.

Elective surgeries were not compared, but the median waiting time for urgent cases was 15 days.