Each week in the game, HouseGuests compete in a series of competitions to win power and safety, they then vote to eliminate, or "evict", one of their own until there are only two remaining.

Big Brother follows a group of contestants, known as HouseGuests, who live inside a custom-built house outfitted with cameras and microphones recording their every move 24 hours a day.

All evicted HouseGuests are eligible to win this award except for those who either voluntarily leave or are forcibly removed for rule violations.

[16] Kaycee Clark, Tyler Crispen, and Kaitlyn Herman all appeared on Big Brother 21 to host separate Power of Veto competitions.

[20] Swaggy C Williams, Bayleigh Dayton, Winston Hines, and Brett Robinson all filmed a promotional video for Love Island, which aired during Big Brother 21.

Kaycee Clark, Fessy Shafaat, Bayleigh Dayton, and Swaggy C Williams appeared on The Challenge: Total Madness.

[27] Kaycee Clark later returned to The Challenge for its World Championship series in 2023, and the milestone 40th season, titled Battle of the Eras in 2024.

However, due to Sam not using her Bonus Life Power App, the evictee was automatically offered chance to win re-entry into the game.

On Day 51, by a vote of 6-1, Bayleigh was the sixth HouseGuest to be evicted from the Big Brother House and became the first member of the Jury.

Following the Power of Veto ceremony, Rockstar calls Angela "entitled" and says that Kaycee "wasn't supposed to go home" after believing that she has the votes to stay.

On Day 58, by a vote of 5-1, Rockstar was the seventh HouseGuest to be evicted from the Big Brother House and became the second member of the Jury.

On Day 65, by a unanimous vote, Scottie was the eighth HouseGuest to be evicted from the Big Brother House and became the third member of the Jury.

On Day 72, by a vote of 4-1, Faysal was the ninth HouseGuest to be evicted from the Big Brother House and became the fourth member of the Jury.

Following his eviction interview, Julie informed Faysal of his chance to return to the game via the Jury Battle Back.

In reality, it was part of fellow Big Brother 18 HouseGuest and boyfriend Victor Arroyo's plan to surprise her with a proposal, which she accepted.

Then, former Big Brother HouseGuests Derrick Levasseur, Britney Haynes, Daniele Donato, Josh Martinez and Paul Abrahamian arrived at the house to celebrate Victor and Nicole's engagement.

Angela became the 14th HouseGuest to be evicted from the Big Brother House and joined the Jury as the eighth member.

Former Big Brother competitor Jeff Schroeder entered the house and the four looked back on the summer, highlighting their favorite moments.

On Day 99, as HoH Kaycee cast the sole vote to evict JC from the Big Brother house.

Later on Day 99, Kaycee Clark was declared the winner of Big Brother 20, by a final Jury vote of 5-4, against Tyler Crispen.

[73] CBS began allowing online applications in September 2017, however open casting calls did not begin until March 2018.

[74][75] Celebrity Big Brother winner and runner up Marissa Jaret Winokur and Ross Mathews host a new companion show known as Off the Block with Ross and Marissa following the end of former House Guest Jeff Schroeder's Big Brother Live Chat.

[77] Joseph Charles "JC" Mounduix received criticism after he was shown using an ice cream scoop on the genitals of his other HouseGuests.

In Week 3, Herman's then-boyfriend released a statement on Twitter, stating that he wanted to distance himself from the show and situation.

[85] Joseph Charles "JC" Mounduix was criticized by fans after he asked Rachel Swindler if she was transgender, stating that she has "a big Adam's apple."

[96] The producers later released a statement saying that neither Crispen nor Broucher filed official complaints and that the two had expressed to them that they "did not feel threatened or unsafe by Mounduix's actions.

Following two articles published by The New Yorker by Ronan Farrow in July and September 2018, where several women accused Chen's husband Les Moonves of harassment, intimidation, and sexual misconduct, effective September 9, 2018, Moonves departed CBS Corporation as President, Chairman and CEO, with Joseph Ianniello appointed as President and Acting CEO.

"[103] The new sign-off broke with an established pattern that Chen has used in the past on Big Brother and showcased her support for her husband, while it received a mixed response from fans and viewers on Twitter.

[104][105] Chen subsequently announced her departure from The Talk in a pre-recorded segment that aired on the September 18, 2018 episode, where she stood outside the Big Brother house.

[106] The 20th season had been confirmed since August 10, 2016 as part of a two-year renewal between CBS and Fly on the Wall Entertainment, in association with Endemol Shine North America.