Keeler Creek is a tributary of the Susquehanna River in Wyoming County, Pennsylvania, in the United States.

A few tenths of a mile further downstream, the creek reaches its confluence with the Susquehanna River.

[1] Keeler Creek joins the Susquehanna River 206.56 miles (332.43 km) upriver of its mouth.

[1] The surficial geology in the vicinity of the lower reaches of Keeler Creek mainly consist of alluvium (containing stratified sand, silt, and gravel), Wisconsinan Outwash, and sand and gravel pits with steep sides that can be dozens of feet deep.

[7] Keeler Creek was entered into the Geographic Names Information System on August 2, 1979.

[4] The North Branch Canal historically had an aqueduct that crossed Keeler Creek.