The southern segment of KY 379 is a 6.751-mile-long (10.865 km) supplemental road in eastern Cumberland County.

[1] The northern segment of KY 379, which extends 20.732 miles (33.365 km) in western Russell County, is a rural secondary highway from its southern terminus near Button north to KY 55 at Olga and a state secondary highway from Olga to its northern terminus in Russell Springs.

The highway crosses Potts Branch and Millers Creek on either side of Creelsboro, where the route meets the south end of KY 1058.

KY 379 crosses Ramsey Creek on its way to Helms, where the route turns north and leaves the valley of the Cumberland River.

KY 379 intersects KY 3280, which heads west along Blair Schoolhouse Road and east along French Valley Road, and crosses the Cumberland Parkway before entering the city of Russell Springs along Main Street.