KY 380 begins at an intersection with KY 272 (Canton Street) in the west-central part of Hopkinsville, within Christian County, where the roadway continues as Navaho Trail.

It intersects KY 695 (Cox Mill Road) and curves to the east-southeast.

It intersects KY 107 (Lafayette Road / South Virginia Street).

It travels along the northern edge of Hopkinsville Country Club golf course and curves to the east.

It crosses over some railroad tracks of CSX and curves back to the northeast.