The highway travels through rural areas of Marion County.

KY 426 begins at an intersection with KY 84 (Raywick Road) south-southwest of St. Mary, within the central part of Marion County.

It travels to the east-southeast and curves to the southeast before meeting its eastern terminus, an intersection with U.S. Route 68 (US 68) and KY 55 (Jane Todd Crawford Trail / Campbellsville Road).

Here, the roadway continues as Mullins Lane.

[1] The entire route is in Marion County.