Keoni Beau DeRenne (born April 30, 1979) is an American professional baseball coach for the Kansas City Royals of Major League Baseball (MLB).

DeRenne attended ʻIolani School in Honolulu, Hawaii, graduating in 1997.

The Atlanta Braves selected DeRenne in the 12th round of the 2000 MLB draft, and he played in Minor League Baseball for the Braves, New York Yankees, Arizona Diamondbacks, Boston Red Sox, and Philadelphia Phillies organizations for eight seasons, followed by another three seasons in independent league baseball.

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