[1][2][3] He previously represented Vijayawada Parliamentary constituency as a Member of Parliament.

At the Lok Sabha, Nani is currently a member of Indian Council of Medical Research committee.

On 10 January 2024, Nani has resigned as the Member of Parliament and left TDP to join the YSR Congress Party.

[6][7][4] Nani contested 2024 Indian general election from Vijayawada Lok Sabha constituency representing YSR Congress Party.

He was defeated by his own brother Kesineni Chinni by a landslide victory with a record margin of 2,82,085 votes.