[1] In 1973, Murali Mohan debuted in Jagame Maya, produced by Atluri Poornachandra Rao.

He gained recognition with the 1974 film Tirupati, directed by Dasari Narayana Rao.

He contested in the 15th Loksabha elections in 2009 as the TDP candidate from Rajahmundry parliamentary constituency of Andhra Pradesh, which eventually lost to the Indian National Congress candidate Vundavalli Aruna Kumar by just 2,147 votes.

He shifted gears in 1963 and started his own business dealing in electrical motors and oil engines.

[7] The Murali Mohan Charitable Trust[8] provides free education for people who secure 85% in both SSC and intermediate and below 10,000 rank in EAMCET or any other preferred entrance tests.