Keswick Creek and Glen Osmond Creek together form a watercourse flowing through the inner south-eastern, south-western and western suburbs of the Adelaide metropolitan area, in the Australian state of South Australia.

[1][2] The water course has been extensively altered since European settlement to manage stormwater flows and avoid flooding in the heavily populated urban areas through which it passes.

[2] A second stream known as Parklands Creek flows through the southern Adelaide Parklands and once ran roughly parallel to the Glen Osmond from an adjacent source in the hillside suburb.

From there flows are typically directed via a constructed drain through the inner western suburbs of Keswick, Mile End South, Richmond, Cowandilla, West Richmond and Brooklyn Park before draining along the eastern edge of Adelaide Airport to join Brown Hill Creek near Netley and ultimately the sea via drains to the Patawalonga River.

To manage stormwater volumes the flows may alternatively be diverted into Brown Hill Creek earlier at the inner south suburb of Forestville, at which point Brown Hill Creek also takes the form of a constructed drain.