The best-known and/or longest-running titles are Amika, Dag Sinterklaas, De Boomhut, Karrewiet, Kulderzipken, Mega Mindy, Samson en Gert, Spring, and W817.

Programs were broadcast to young teenagers such as Studio.Ket, King of the Hill, NBA Jam, Ultratop, Ready or Not and Married... with Children, among others.

Since Ketnet underwent a major renewal operation in April 2006, many old (regular) programs have disappeared from the programming, including Zorro, Skippy, Tintin, Once Upon a Time..., The Busy World of Richard Scarry, Tik Tak, Bassie and Adriaan, Allemaal beestjes, Alfred J. Kwak, Hey Arnold!, Liegebeest, Postbus X and Pingu.

As with VRT's main television station één, Ketnet employs in-vision continuity announcers.

On 17 November 2007, Ketnet launched KetnetRadio, an online radio station consisting of a looped 3-hour programme, broadcast for 24 hours.