Keystone Wye is an interchange of U.S. Route 16 (US 16) and US 16A located in the Black Hills of South Dakota, featuring two unique structural glued laminated timber bridges.

The high bridge is supported by three 20-meter (66 ft) wooden, single-hinged arches; six separate glued laminated timber pieces are used in the construction.

[1] The name "Keystone Wye" significantly predates the construction of the modern interchange and dates back to the 1930s and the construction of Mount Rushmore, when Senator and Governor Peter Norbeck laid out a series of roadways in the south-central Black Hills for tourist travel, focusing on Mount Rushmore and Harney Peak (now Black Elk Peak).

The Keystone Wye includes a lay-by with historic and scenic information about the area, a SDDOT maintenance yard, and several minor roads connecting to the major highways.

In the early 2000s, US 16 between the Keystone Wye and Three Forks was improved to a "Super-Two" configuration with passing lanes on most hills, although the alignment was unchanged from the 1980s realignment project which created many cutoff loops on the highway.