[4] The building was named after local philanthropist and merchant Ghulam Hussain Khaliqdina, who was instrumental in the establishment of the Sindh Madressatul Islam.

Khaliq Dina Hall was used as the court for the 1921 "Trial of Sedition" in which British authorities put Maulana Shaukat Ali and Maulana Mohammad Ali Jouhar on trial for mutiny as they made speeches in support of the Khilafat Movement.

[8] The hall was also used after Pakistan's independence as a site for Majlis during the last ten days of Muharram, which were addressed by the eminent Islamic scholars Allama Rasheed Turabi, Allama Aqeel Turabi and Dr. Kalbe Sadiq[9] In 1970, Dada Amir Haider Khan, a Communist activist, gave a speech in the hall.

[12][13] Its most notable feature is the 10 foot wide veranda and triangular pediment supported by 12 Greek-style Ionic pillars at the front,[11] which makes the building resemble an ancient Greek temple.

The pediment is inscribed with the name of the building, and date of construction - Ghulam Hoosain Khalikdina Hall and Library 1906.