Khlong Sapphasamit (Thai: คลองสรรพสามิต) is a man-made waterway and one of the important water resources in Samut Prakan province on outskirts Bangkok.
It was excavated in 1939 by the government of Pridi Banomyong, Minister of Finance in those days (match the King Rama VIII's reign) for salt transport, the main products of the province.
Later, a canal was dug through to the Tha Chin river in Samut Songkhram province, total distance about 30 km (18.6 mi).
There are lots of nipa palms in the mangrove forest along both sides of the canal, especially in the Ban Na Kluea area.
Khlong Sapphasamit is an important source of water for small-scale local fishermen including being another cultural tourism route in Samut Prakan.