KSS is located on Kibuli Hill, in Makindye Division, in the south-central part of the city of Kampala, Uganda's capital and largest city.

The coordinates of Kibuli Secondary School are:0°18'38.0"N, 32°35'51.0"E (Latitude:0.310556; Longitude:32.597500).

[1] The school is affiliated with the Muslim faith, but admission is based on academic performance and is open to any interested student, regardless of religious beliefs.

The school has a reputation of being a leading academic center with a history of sporting achievements.

[2] Prince Badru Kakungulu, a Buganda Royal, who lived during the early 20th Century, donated 80 acres (32 ha) on Kibuli Hill, where the school was constructed.