Kisatchie Bayou is a series of interconnected, natural waterways totaling over 38 miles in length in Natchitoches Parish, Louisiana, and Sabine Parish, Louisiana.

The bayou is a tributary of Old River at Isle Brevelle.

The bayou runs through a large portion of Kisatchie National Forest, the only national forest in the State of Louisiana.

Several of the swimming scenes with actress Reese Witherspoon were filmed at the bayou and the falls.

[4] The name Kisatchie is derived from a tribe of Kichai Indians of the Caddo Confederacy.