The community of Sherridon is on its eastern shores, and the Kississing Lake Indian Reserve is on the western side.

[5] The lake is the main resource for Sherridon residents, since it is home to several fishing lodges and outfitters, and used by commercial fishermen, trappers, and wild rice growers.

[6][7] Kississing Lake lies near the height of land on the southern edge of the drainage basin of the Churchill River, and is part of the Hudson Bay watershed.

The main part of the lake, as well as all its bays and arms are filled with numerous rocky islands, both large and small.

[2] Since it lies close to the height of land, none of the streams in its vicinity are large, and the country is poorly drained.

In 1923, deposits of copper-zinc sulphides were staked on the east shore of the lake, which were developed into the Sherritt-Gordon Mine.