Taking place ten years after the events of the original Kite film, this second installment opens with Kōichi Doi, a researcher for Defy Foods, boarding the International Space Station.

However, the lights go out in the restroom and he is attacked by the female assassin known as "the Angel of Death", who quickly disarms and shoots him, leaving a pile of white feathers on his corpse.

Later that night, Monaka, the girl that currently assumes the same murderous tactics as Sawa, goes to work at Apollo 11, a maid café with a perverted regular patron.

Monaka plays the part of a nerdy, clumsy high school girl while in public, making her a vulnerable target for harassment.

Monaka's older co-worker Manatsu Mukai does not take kindly to that, however, and retaliates in several occasions, such as spiking his drink with habanero or kicking him in the groin.

The onboard doctor realizes the condition was caused by a combination of the space radiation and Doi's food, which is allowed to be shipped to the station without proper lab test.

The next morning, Monaka makes plans for her next target, a real estate agent who is in fact a serial killer that uses an apartment under his brokerage to carry out murders.

The doctor and Doi, along with the others, are able to escape the station, though the incident draws Defy Food Company to hire agents to get rid of evidence that may jeopardize their reputation.

She offers to buy him drinks and then to quit her waitress job in exchange for him not notifying the school about her working at the maid café as a minor, although he instead agrees to settle with a date.

It hesitates, giving her enough time to shoot it through the mouth, which proves to be a weak point, causing the monster to fall onto a passing car that happens to be part of a convoy that Doi is travelling with.