Kitsu Creek is a tributary of Mess Creek and part of the Stikine River watershed in northwest part of the province of British Columbia, Canada.

[1][6] It flows generally northwest and north for roughly 22.5 km (14.0 mi)[4] to join Mess Creek, a tributary of the Stikine River.

Its watershed covers 72.6 km2 (28.0 sq mi) and is entirely in Mount Edziza Provincial Park.

[5] The mouth of Kitsu Creek is located about 47 km (29 mi) south of Telegraph Creek, British Columbia, about 115 km (71 mi) southwest of Dease Lake, British Columbia, and about 228 km (142 mi) southeast of Juneau, Alaska.

[9] Kitsu Creek's watershed is in the southern part of the Mount Edziza volcanic complex.