It lies at the eastern edge of the Kraichgau in the centre of a rectangle that is formed by Heidelberg, Karlsruhe, Heilbronn, and Stuttgart.

In 1360, in 1632 and again in 1692, the town was completely destroyed, having suffered greatly from being besieged, set on fire and sacked.

In 1632 during the Thirty Years War, Knittlingen was burned down by troops of General Ernesto Montecuccoli who fought on the side of the Empire.

The important market road from Frankfurt am Main to Cannstatt via Speyer runs through the center of Knittlingen.

The Dr. Johannes-Faust-School is an elementary and secondary school and is attended by nearly 1000 students from all over the Enz (district).

The Badischen Neuesten Nachrichten (BNN), a daily newspaper operating out of Karlsruhe and the Pforzheimer Zeitung.