Knob Lick is an unincorporated community in southern Saint Francois County, Missouri, United States.

Knob Lick has a post office with zip code 63651,[3] which has been in operation since 1870.

Eighty (80 acres (32 ha)) of the summit are protected by the Missouri Department of Conservation.

A gravel road leads to the conservation area which includes a granite glade, picnic facilities, and a closed fire lookout tower.

This Saint Francois County, Missouri state location article is a stub.