The team tries to diagnose a teenage girl while House is away at a medical conference with Wilson and Cuddy.
After a wild night out, a teenage girl named Jordan (Anna Attanasio) is brought to Princeton Plainsboro with severely swollen appendages.
But the CT shows no signs of trauma, so House goes in and gets Jordan to pretend to play the drums.
Meanwhile, Cuddy, Wilson, and House spend a weekend away from the hospital to attend a medical conference.
House tells her that the next morning he was going to see her and see where things would go from there, but he got a call from the Dean of his first medical school and found out that he was expelled.
Jordan's friend, Phoebe, tells Cameron and Chase what they did the previous night, stating they followed comic book creator Jeffrey Keener (Marcus Giamatti), including going to a restaurant in the building.
The food makes Foreman suspect she could be bulimic, which would account for all her symptoms, so Cameron starts her on nutrition supplements and they do a barium swallow to check for mallory weiss tears.
House notes that since her blood pressure dropped during the barium swallow, it can't be a chronic condition.
CCTV tapes show she was gone for only five minutes, and she returned from her trip holding Keener's journal.
Jordan also admits that she never plucked up the courage to knock on Keener's door, so she left his notebook on his doormat.
Later, Wilson also admits that it was irrational to sacrifice his career because of his remorse and thanks House for being a good friend.