The church was commissioned in 1720–1722 by the boyar Iordache Crețulescu and his wife Safta, a daughter of prince Constantin Brâncoveanu.

Originally, the exterior was painted, but since the restoration work done in 1935–1936 (under the supervision of architect Ștefan Balș [ro]), the façade is made of brick.

In the early days of the communist regime, Kretzulescu Church was slated for demolition, but was saved due to efforts of architects such as Henriette Delavrancea-Gibory.

To the side of the church now stands a memorial bust of Corneliu Coposu.

This article on an Eastern Orthodox church building in Romania is a stub.