At 18, Cazaumayou started a career in advertising which lasted for ten years, but in 1970 he entered the field of bandes dessinées, releasing his first album, Kris Kool.

[1] With the emergence of the magazine Métal Hurlant in 1975, Caza began to supply work within the science-fiction genre, with titles such as Sanguine, L'oiseau poussière, initially working with an exhaustive black and white dot technique.

This was later abandoned for a style of colour use which would become a trademark, as seen in later work such as Arkhê, Chimères and Laïlah.

[2] From 1985 to 1987, he worked closely with René Laloux on the animated film Gandahar, based on the novel by Jean-Pierre Andrevon.

In 2002–2003, he worked with Philippe Leclerc on the animated film The Rain Children, based on a novel by Serge Brussolo.