It extends north from the major shopping street Strøget to Grønnegade where it turns into Gammel Mønt.

Together with Bremerholm, its extension to the south, it forms one of only two places where car traffic crosses pedestrianized Strøget on its way from Kongens Nytorv to the City Hall Square, the other being at Gammeltorv-Nytorv.

They include the shopping archade Galleri K. In the Middle Ages, the site was an open sewer which continued to the harbor.

45 in Købmager Quarter, owned by restaurateur Johan Georg Egner.

The department store Chrom & Gldschmit opened on the corner with Østergade (Strøget) in 1887.

An initial proposal for a renewal of the buildings along the street by the architects Henrik Hagemann and Alfred Møller was not used.

Today, Kristen Bernikows Gade 1 houses the Embassy of Canada as well as the Danish affiliate of the international media agency group GroupM.