The character will make his live-action cinematic debut in the upcoming film Superman (2025), an installment of the DC Universe (DCU) media franchise.

[1] Originally intended as a one-off character, the dog attracted positive attention from the audience, and returned four issues later and became a regular member of Superboy's cast.

[2] On Krypton, parallel evolution leads to the emergence of analogous species to Earth birds, dogs, cats, and simians.

When not accompanying Superboy/Superman, Krypto spends much of his time romping through space;[5] while on Earth, however, he stays with the Kent family, posing as their pet dog, "Skip".

[13] Asked in a 2006 interview why he "liberated Krypto from the limbo kennel", writer Elliot S. Maggin said, "A man needs a dog.

Following the Crisis on Infinite Earths continuity reboot, Superman's history is extensively rewritten, initially eliminating Krypto and all other survivors of Krypton.

[16] While battling three Phantom Zone criminals, Krypto sacrifices his powers by giving Superboy gold kryptonite to depower them.

Soon after, the dog finds two young children who were trapped in a bomb shelter for a month following Superman's fight with Doomsday.

This gives Superman the idea to explain Clark Kent's long absence by staging a faked rescue from a similar predicament.

Along with a creature called Grokk the Living Gargoyle and a DNAlien named Angry Charlie, Krypto starts an uprising against the Agenda, an evil consortium which is influencing Cadmus at the time.

This initially causes a great deal of trouble for his new master when, for instance, he would scratch at a door to indicate he wanted to go out and unintentionally gouged big chunks out of the door with his super strength, or inflicting grievous bodily harm when combating villains (since Krypto bites the way a regular canine would, only without being careful about his super strength).

Krypto operates on his own for a short period of time, helping out when disasters rocked the planet because of the plans of the invading Imperiex.

[20] In the "Hush" story arc, Batman uses Krypto to find Poison Ivy after she uses kryptonite to control Superman.

Thinking Batman and Superman needed to be rescued from President Lex Luthor, a small team of superheroes, which includes such heroes as Superboy, Nightwing, and Robin, invade the White House.

Krypto makes a brief appearance in JLA #87, where Martian Manhunter mind-controls him after his evil Fernus persona resurfaces.

Along with other Earth-based heroes influenced by alien origins, Krypto attacks Superman and Batman after a gathering in Metropolis.

Although Action #850 does not deal with the specifics of how or when this dog was sent to Earth, subsequent issues of the Superman title have contained references to Krypto being around when he was "young".

Both inclusions retconned the origin of the current Krypto hailing from an ersatz Krypton and debuting during Superman's adulthood.

Under Robin's command, Krypto attacks Prime with feral rage, damaging his armor, but is unfortunately beaten aside, although he buys the heroes enough time for Superman, Power Girl, and Supergirl to join the fight.

[29] The character appears alongside the resurrected Conner Kent as his companion and sidekick, with a much more amicable relationship than before Connor's death.

Krypto is instrumental in helping Conner Kent escape the effects of a Black Lantern power ring.

In Action Comics #5 (March 2012), during Krypton's final moments, Jor-El tries to save his family by opening a portal to the Phantom Zone, when suddenly the incarcerated try to escape.

[33] Krypto bravely defends the family but is sucked into the Zone, while baby Kal-El shows anguish at losing the dog.

The now-grown Superman rediscovers Krypto in Action Comics #13 (December 2012) after being pulled into the Phantom Zone by the first inhabitant of the prison.

Krypto assists Superman and Supergirl in fighting various groups of Warworld challengers, as a delaying tactic to save Earth from destruction.

[39] The Super-Sons annual of 2017 explores Krypto's friendship with various super-animals, such as Titus, Batcow, Streaky, and Detective Chimp.

He also had super-canine intelligence (approximately human level, though with his canine traits and interests still present); the comics expressed this via the use of thought balloons indicating what Krypto was thinking.

In DC League of Super-Pets, Krypto gains a new powerful move called the solar paw punch.