Among the archaeological ruins on Kulusuk the ancient settlement of Ikaasap Ittiva (Ikâsap Igtiva) is located near the shore at the northern end of the island.

The southernmost point is the Naujaangivit cape (Danish: Kap Dan[4] − a name often extended to the settlement or the island) under the Isikajia mountain (336 m (1,102.4 ft)).

In the north, the Torsuut Tunoq sound separates it from the small, uninhabited Akinaaq island, ultimately linking it to the Ammassalik Fjord in the northwest.

The largest of the latter is Tiivtingaleq bay to the southwest of the settlement, host to a small harbour used both in all seasons as a starting point for hunting trips.

The highest point on the island is the summit of Qalorujoorneq, at 676 m (2,217.8 ft)[4] topping a wide mountain massif in the southeast, directly above the Kulusuk Airport.