The school was started as a private secondary school for girls by Caxton Williams, a Sierra Leonean in 1953.
Kumasi Girls' Senior High School (KUGISS) was first situated at Susanso, near Bomso Junction on the Kumasi-Accra road.
In the early 1960s, the proprietor moved the school to Old Tafo where it remained in rented premises until 1992 when the school was moved to its present and permanent site at Abrepo.
Kumasi Girls maintains an ongoing alliance with their boys' school, Kumasi High School called MMRAHEMMAA.
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