[11][12] The start-up phase of the Kunsthaus was managed by Alfons von Uslar, who was Honorary Founding Managing Director from 2020 to June 2022,[13] and by Ute Eskildsen, retired curator of the Folkwang Museum in Essen, who advised on the building planning and organised the first two exhibitions.

As of February 2023, Dr. Dorle Meyer leads the Kunsthaus's operations as Managing Director and the Curator Lotte Dinse has been responsible for content since 2023.

[22][23] On the south side of the inner courtyard lies the "House of Words" pavilion, which opened shortly after the Kunsthaus in the summer of 2021.

[26] As a partner project of documenta fifteen, the Kunsthaus opened a group exhibition titled Printing futures[27] from June 18 to September 25, 2022, which presented internationally known artists such as Dayanita Singh, Theseus Chan and Shahidul Alam.

It was initiated by Rolf-Georg Köhler (retired mayor) and Alfons v. Uslar (former founding managing director of the Kunsthaus).