[4] He served as the Chairman of the Public Accounts Committee in the immediate-past Parliament and was the acting CEO of the National Health Authority in 2006, and also the deputy Minister of Finance and Economic Planning under former President Kufuor's administration (2001 to 2008).

[10][1] In this government, he served a Deputy Minister of State in the following Ministries: Trade and Industry, Interior, Finance, Communication and Roads and Transport.

Mr. Woyome then sued the Government of Ghana in 2009 and secured a judgment of over GHC 51 million, relying on the letter issued by Mr. Kwaku Agyemang Manu.

In an attempt to quell the issue, the Minister was heard on a local radio station, Adom FM, refuting the allegations of tender procurement breaches.

This scandal was widely covered in the local media and many wondered why the Minister was still at post after these hard facts leveled against him had caused the loss of many lives in the country due to the shortage of this all important emergency drug.

[23][24] A locally registered company owned and managed by Indian nationals has been active in Ghana since 2005 and has increasingly won many tenders especially under the tenure of Kwaku Agyemang Manu as the Minister of Health.

No full-blown investigations have been started by the Government of Ghana whilst evidence of fraud and tender manipulation has been widely published by local media.

[25][26][27] Kwaku Agyemang-Manu was admitted on Tuesday and was released on Friday whiles his wife and son are in critical conditions at the intensive care unit of UGMC.

He claimed that he hasn't tested positive on COVID-19 on Saturday when he spoke via phone to a journalist called Afia Pokuaa aka Vim Lady.

Kwaku Agyeman-Manu has been called to serve on the executive board of the World Health Organization (WHO) as the representative of Ghana who is a member state of the WHO.