Between 1997 and January 2000, he served as Ghana's Ambassador to Cuba with concurrent accreditation to Jamaica, Trinidad and Tobago, Nicaragua and Panama.

[5][6] His doctoral thesis was titled ''The Political Biography of Dr. Kofi Abrefa Busia'', a Ghanaian politician who was the second Prime Minister of Ghana.

[8][9] In 1997, he took a break from lecturing to serve as Ghana's Ambassador to Cuba with concurrent and multiple accreditation to Trinidad and Tobago, Jamaica, Nicaragua and Panama.

[10] In January 2009, after his party won the 2008 elections, Danso-Boafo was given a role to serve as a member of John Atta Mills' transition team, working under the International Relations sub-committee.

He was later appointed by John Evans Atta Mills to serve as Ghana's High Commissioner to the United Kingdom and Ireland.

[13][4] In January 2000, Danso-Boafo was appointed by President Jerry Rawlings to serve as Minister for Health taking over from Samuel Nuamah Donkor.

His party however lost power in the December 2000 elections which meant the end of his ministerial work in January 2001 when the new government assumed office.

[21] On 11 December 2013, he was honoured as a fellow of the Ghana College of Physicians and Surgeons for his contribution to medical education and research at the postgraduate level.