In March 2014, he was appointed the managing director of the Intercity State Transport Company limited (STC) in the National Democratic Congress, under John Mahama administration from 2014 to 2017.

Samuel Nuamah Donkor was born on 5 September 1958 to Opanin Kwabena Agyekum, Gyaasehene of Asokore-Koforidua in the Eastern Region of Ghana and Madam Abena Akyaamah also from Asokore- Koforidua.

[4][5] He began his political career in 1982, appointed by chairman Jerry John Rawlings of the Provisional National Defence Council PNDC as the Deputy regional coordinator for Peoples Defence Committees and Workers Defence Committees (PDCs / WDCs) and additional position as coordinator for New Juaben North 1982 to 1992, when he became the parliamentary candidate for the National Convention Party (NCP) to represent his constituency in the Eastern Region of Ghana prior to the commencement of the 1992 Ghanaian parliamentary election.

[7][3][8] He was sworn into the First Parliament of the Fourth Republic of Ghana on 7 January 1993 after being pronounced winner at the 1992 Ghanaian election held on 29 December 1992.

After serving his four years tenure in office, Samuel Nuamah Donkor lost his seat in the 1996 Ghanaian General Elections to his counterpart in the New Patriotic Party (NPP), Hackman Owusu Agyemang who polled 11,629 votes which represented 52.60% of the total votes cast.

[citation needed] He was awarded a certificate of honour by the Ghana medical Association (GMA) in its annual conference held in Suyani in the Brong Ahafo Region.