By road, it is approximately 175 kilometres (109 mi) from the capital Kampala, and is connected with nearby towns of Butemba to the west, Bukomero to the southeast, and Kiboga about 55 kilometres (34 mi) to the south via Bukwiri on Kampala-Hoima Road.

Kyankwanzi is situated along the "cattle corridor," heavily inhabited by the cattle-keeping Banyankole and Banyarwanda residents.

As such, Kyankwanzi has long been known to the public as the location of the National Leadership Institute (NALI), a government institute, established here because of the history of the Ugandan Bush War by the National Resistance Movement to train national leaders in the public service, military, government security organs and willing members of the populace.

The Kyankwanzi District Headquarters' seat is rather in Butemba Town, located closer to Kampala-Hoima Road.

The following points of interest lie within the town limits or near its borders: