[1][2][3] He played college baseball for the Dartmouth Big Green under head coach Bob Whalen.

[7] The Cubs acquired Hendricks alongside Christian Villanueva in exchange for Ryan Dempster at the 2012 trade deadline.

[15] Hendricks tied for seventh place with Travis d'Arnaud and Jeurys Familia in the NL Rookie of the Year Award voting.

[16] Hendricks began the 2015 season as a member of the Cubs' starting rotation, led by the newly signed Jon Lester.

The Cubs won the 2016 World Series over the Cleveland Indians, with Hendricks as the starting pitcher in Games 3 and 7, giving them their first title in 108 years.

[23] On June 8, 2017, Hendricks was placed on the 10-day disabled list (transaction retroactive three days prior) due to middle finger tendon inflammation in his right hand.

He tied for the major league lead in pickoffs, with seven, while allowing 13 stolen bases and having four caught stealing.

[27] He was the losing pitcher in the NL Wild Card Game, giving up three straight hits and one run in the 13th inning against the Colorado Rockies.

[34] Hendricks also finished ninth in Cy Young voting, tying Zac Gallen and Clayton Kershaw in the process.

[35] On April 18, 2021, in a game against the Atlanta Braves, Hendricks allowed home runs to Freddie Freeman, Travis d'Arnaud, Ehire Adrianza, and Guillermo Heredia all in the first inning, becoming the first pitcher in Cubs history to allow four home runs in the first inning, and only the ninth player in history to accomplish the feat.

His last start was made on July 5, after which it was discovered that he suffered a capsular tear in his shoulder and would miss the remainder of the season.

[43] His father, John, is a golf pro; his mother, Ann Marie, is a medical management consultant.

[43] He earned his bachelor's degree in economics from Dartmouth College in December 2013, after completing his coursework in the winter of 2012 and fall of 2013.