In 2016, Isbel's freshman season at UNLV, he hit .319 with one home run and 28 RBIs over 56 games, earning Mountain West Conference co-Freshman of the Year honors.

[9][10] In 2018, his junior year, Isbel slashed .357/.441/.643 with 14 home runs and 56 RBIs over 59 games,[11] earning All-MW First-Team honors.

[13][14][15] Isbel signed with the Royals and made his professional debut with the Idaho Falls Chukars before being promoted to the Lexington Legends.

On March 31, 2021, Royals manager Mike Matheny announced the Isbel had made Kansas City's Opening Day roster and would be starting in right field.

[25] On September 3, 2022, in a 12–2 win over the Detroit Tigers, Isbel hit his first career grand slam off of reliever Jason Foley.