After starting and gaining the victory on Opening Day 1991 against the Texas Rangers, Knudson contracted a virus that seriously affected his performance.

[citation needed] He missed most of that season and was sent to Triple-A Denver to finish the year, where he helped the Zephyrs win the American Association championship.

Knudson spent the 1992 season in the San Diego Padres organization before signing with the expansion Colorado Rockies in 1993.

[citation needed] During his career, Knudson posted wins over three of the four members of the 4,000 strikeout club, Nolan Ryan, Roger Clemens and Randy Johnson.

[citation needed] Since retiring, Knudson has worked for the Rockies in community relations, and began a career in sports media.