He played college football at the University of Missouri, and was selected by the Atlanta Falcons with the 19th overall pick in the 2010 NFL draft.

He was named the Texas District 22-3A player of the year as a senior; after making 98 tackles in 2005 for the Jasper Bulldogs.

He was named the 22-3A defensive newcomer of the year as a sophomore in 2003; when he amassed 101 stops, 3 tackles for loss, 1 QB sack and 2 interceptions.

At the 2005 District 22-3A Championships, he won the high jump event with a leap of 1.89 meters (6-2), and ran the fourth leg on the Bulldogs 4 × 200 relay, helping them earn a first-place finish with a school-record time of 1:30.62 minutes.

Weatherspoon was listed as the backup on the depth chart at middle linebacker to senior co-captain Dedrick Harrington, and had 17 tackles in all for the season.

As a sophomore, Weatherspoon became a starter at weakside linebacker and blossomed into a leader on the field, under the tutoring of coach Dave Steckel.

In 2008, Weatherspoon finished the season with 155 tackles, which were the 2nd-most in Missouri single-season history, trailing only to Travis McDonald (164 in 1994).

[13] On June 10, 2014, the Falcons announced that Weatherspoon would miss the entire 2014 season with a ruptured Achilles tendon.

[16] On October 4, 2016, he was placed on injured reserve after suffering a torn Achilles in a Week 4 win over the Carolina Panthers, ending his season.