Stowers made his major-league debut as the starting left fielder batting eighth in an 11–1 loss to the Toronto Blue Jays at Rogers Centre on June 13, 2022.

[13][14] He and Rico Garcia had been promoted from the Norfolk Tides earlier that day as substitutes for Anthony Santander and Keegan Akin who were both placed on the restricted list for having been unvaccinated against COVID-19 at the time.

[17] His first-ever MLB home run was a two-out 0–2 pitch off Liam Hendriks which he sent to the bleachers in center field in the bottom of the ninth to tie at 3–3 an eventual eleven-inning 4–3 Orioles victory over the Chicago White Sox at Camden Yards six days later on August 25.

[20] He surpassed Christian Walker for most career home runs in Orioles minor-league affiliate history with three in a 26–11 away win over the Charlotte Knights on April 3.

[22] Two weeks after his recall by the Orioles on May 13,[23] he established an MLB-career-high four RBI with three hits including two doubles in an 11–3 home win over the Boston Red Sox on May 27.