[6] L.A. by Night is a sequel to Vampire: The Masquerade – Bloodlines and deals with the fallout from the game for Kindred society in Los Angeles, however, the events of the show center on a different group of characters.

[12] The show was in part intended to promote Legendary Digital Networks' streaming platform Alpha, premiering there as well as on Geek & Sundry's Twitch channel.

[13] The first three seasons featured many guest characters portrayed primarily by actors from other LDN shows- including Marisha Ray and Taliesin Jaffe of Critical Role, Jessica Chobot and Hector Navarro of Mothership, and Jason C. Miller of Starter Kit.

With Geek & Sundry in decline and facing major layoffs in 2020,[17] production of the show was taken over by Paradox Interactive (owner of World of Darkness intellectual property such as Vampire: The Masquerade).

Farough wrote that the show "was created to give Vampire: The Masquerade and its community more visibility among a wider roleplaying audience, thanks in part to a partnership with Geek & Sundry.

Once you're immersed, the effect is reminiscent of old-timey radio shows where a cast of characters would react as a narrator weaved a tale of adventure, mystery, or science fiction".

[24] The show was also on Screen Rant's 2021 "RPG Actual Plays Like Critical Role To Check Out For Halloween" list — the article states that "as a campaign where players are the monsters, much of the horror, tension, and humor in LA By Night stems from the player characters themselves and the harsh choices they make to appease their thirst for blood, advance their status in the cutthroat politics of vampire society, and the danger they face from the vampire-hunting forces of the Second Inquisition (should they flaunt their vampire status overmuch)".

[2] Colin Kerford, in a separate article for Screen Rant, highlighted that over the course of the show it has "brought together a star-studded cast of actors" and that "while it is at its core a live-play of a tabletop RPG, the series sets itself apart with higher production values than many others, including detailed makeup and costume work as well as special effects.

Over the course of its five seasons, the show has functioned as a sort of sequel to Vampire: The Masquerade, telling the story of two of the game's factions set some years after the plot detailed in the book".