[4] Lee's father worked at the props department at the BBC and his mother was a secretary until she developed multiple sclerosis which put her into an early retirement.

[5] Lee began a stand-up comedy career in the 1990s, initially performing on the London circuit exclusively before touring nationwide.

[7] Lee began his radio career in December 1997, presenting a four-hour show on Horizon 103.3, an independent station in Milton Keynes, on Christmas Day.

At that point, he was 24 years old with only fifteen minutes experience in a studio and did not take any compliance or Ofcom regulation exam prior.

Lee embarked on a full-time radio career in January 2005, starting with a stint on talk station LBC 97.3.

In 2007, Global Radio purchased LBC which led to a change in management, who introduced a talk format of topical and news-driven conversation.

His departure occurred during a court case in which a listener was accused of harassing Lee, his wife, and the show's producer.

[10] From 2012 to 2015, Lee presented the weekday breakfast show on BBC Three Counties Radio, a local service that served Bedfordshire, Hertfordshire, and Buckinghamshire.

He left the station in the following August, citing that management considered Lee hosting both slots as "odd" and wanted him to just present on Saturdays, which he rejected.

His departure followed complaints received about his interview with a lawyer from Christian Concern earlier in the month, in which Lee accused her of being "bigoted" and "homophobic" after she defended a minister quoting verses from the Bible condemning homosexuality as sinful.

[15] In February 2016, Lee announced that he had joined the first line-up of presenters for the launch of a new talk radio station, talkRADIO.

[19] On 10 July 2020, Lee announced that he had been signed by Twitch to continue hosting The Late Night Alternative on its streaming platform.

[4] In January 2000, Lee and co-host Daisy Donovan were criticised by Ofcom for making "death jokes" on the recently murdered Jill Dando.

[4] In 2002, Lee accepted to co-host a relaunch of the Channel 4 live breakfast show RI:SE with reality television star Kate Lawler, from January 2003.

[7] Lee described the year 2004 as "absolutely terrible" in regard to his career and started to binge drink to cope with the stress,[4] and spending around £2,000 on cocaine each week.

Later he made regular appearances on Sky News and This Morning, and hosted the Big Brother companion series Bit on the Psych for Channel 5.

[26] From the start of 2018, Lee was on the breakfast TV show Good Morning Britain, filling in for Richard Arnold who was taking a 3-week break.

Fuck Off,[34] a spin-off to the Performer/Audience/Mirror originally conceived in 1975 by American artist Dan Graham, whereby the performer does their act behind a mirror reflecting the audience.

[38] The Late Night Alternative (TLNA) is an online phone-in show Lee and Katherine Boyle hosted on streaming platform Twitch.

[42] On 2 June 2020, Lee announced his contract at Talkradio would not be renewed, having presented his final programme the previous evening.

[44] At the time of the announcement, Lee confessed he had relapsed in drug use after being sober for 13 years,[45] in a three-month period following his stint on I'm a Celebrity... Get Me Out of Here!, to which he credited Katherine Boyle in taking him to an Alcoholics Anonymous meeting.

[46] In July 2019, Lee came out as bisexual on his radio show, something that he had felt embarrassed about and tried to handle it with drugs and extramarital affairs.