It lacks any globular fold or secondary and tertiary structures, placing it in the class of intrinsically disordered proteins (IDPs).

[10] Due to LBHs disordered structure, it may experience multi-functionality through the binding to different targets, producing different transcriptional effects.

[7] LBH was then found to be directly downstream of the canonical Wnt/β-catenin pathway by downregulating the expression of Wnt, preventing signal completion.

[7] Recent studies have found that LBH has a significant role in the regulation of stem cell growth and proliferation in mammary glands.

[8] Inversely, overexpression has been noted in basal subtype breast cancers, furthering LBHs effect on stem cell regulation.

Studies examining the role of Lbh in tumorigenesis in MMTV-Wnt1 transgenic mice as a model for Wnt induced breast cancer development.

Lbh was conditionally deactivated in these transgenic mice, significantly delaying tumor onset and resulted in decreased differentiation and proliferation while also increasing apoptosis.