10288n/an/an/aA2IXV5n/aNM_005874n/aNP_005865n/aLeukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.

The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).

[5] LILBR2 plays a critical role in the inhibition of axonal regeneration and functional recovery after brain injury.

[6] However, recent studies demonstrate that LILRB2 is a β-Amyloid receptor and may contribute to synaptic loss and cognitive impairment in Alzheimer's disease.

[9][10] This article incorporates text from the United States National Library of Medicine, which is in the public domain.